Tait, S. (2013) DNA: leukemia's secret weapon of bone mass destruction. Oncogene, 32(44), pp. 5199-5200. (doi: 10.1038/onc.2012.639)
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Abstract
Interaction of tumour cells with their microenvironment impacts on all aspects of cancer, ranging from development through to treatment response. In this issue, Dvorak and colleagues1 reveal a novel tumour/microevironment relationship that may drive leukemia pathogenesis. Specifically, they find that leukemic cells secrete chromatin-complexed DNA that, in turn, triggers a variety of harmful effects, including cell death, in neighbouring stromal cells. Through this toxicity, DNA-mediated bone marrow destruction could promote disease progression by allowing leukemic cells to exit the bone marrow into the circulation.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Tait, Professor Stephen |
Authors: | Tait, S. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Oncogene |
Publisher: | Nature Publishing Group |
ISSN: | 0950-9232 |
ISSN (Online): | 1476-5594 |
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