Podosomes in adhesion, migration, mechanosensing and matrix remodeling

Schachtner, H., Calaminus, S. D. J., Thomas, S. G. and Machesky, L. M. (2013) Podosomes in adhesion, migration, mechanosensing and matrix remodeling. Cytoskeleton, 70(10), pp. 572-589. (doi: 10.1002/cm.21119)

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Publisher's URL: http://dx.doi.org/10.1002/cm.21119


Cells use various actin-based motile structures to allow them to move across and through matrix of varying density and composition. Podosomes are actin cytoskeletal structures that form in motile cells and that mediate adhesion to substrate, migration, and other specialized functions such as transmigration through cell and matrix barriers. The podosome is a unique and interesting entity, which appears in the light microscope as an individual punctum, but is linked to other podosomes like a node on a network of the underlying cytoskeleton. Here, we discuss the signals that control podosome assembly and dynamics in different cell types and the actin organising proteins that regulate both the inner actin core and integrin-rich surrounding ring structures. We review the structure and composition of podosomes and also their functions in various cell types of both myeloid and endothelial lineage. We also discuss the emerging idea that podosomes can sense matrix stiffness and enable cells to respond to their environment.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Calaminus, Dr Simon and Machesky, Professor Laura
Authors: Schachtner, H., Calaminus, S. D. J., Thomas, S. G., and Machesky, L. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cytoskeleton
ISSN (Online):1949-3592
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
533601The role of podosomes and lamellipodia in megakaryocyte function.Laura MacheskyBritish Heart Foundation (BHF)FS/09/034/27756ICS - BEATSON INSTITUTE FOR CANCER RES.