Socioeconomic status and the cerebellar grey matter volume. Data from a well-characterised population sample

Cavanagh, J. et al. (2013) Socioeconomic status and the cerebellar grey matter volume. Data from a well-characterised population sample. Cerebellum, 12(6), pp. 882-891. (doi:10.1007/s12311-013-0497-4)

Cavanagh, J. et al. (2013) Socioeconomic status and the cerebellar grey matter volume. Data from a well-characterised population sample. Cerebellum, 12(6), pp. 882-891. (doi:10.1007/s12311-013-0497-4)

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Abstract

The cerebellum is highly sensitive to adverse environmental factors throughout the life span. Socioeconomic deprivation has been associated with greater inflammatory and cardiometabolic risk, and poor neurocognitive function. Given the increasing awareness of the association between early-life adversities on cerebellar structure, we aimed to explore the relationship between early life (ESES) and current socioeconomic status (CSES) and cerebellar volume. T1-weighted MRI was used to create models of cerebellar grey matter volumes in 42 adult neurologically healthy males selected from the Psychological, Social and Biological Determinants of Ill Health study. The relationship between potential risk factors, including ESES, CSES and cerebellar grey matter volumes were examined using multiple regression techniques. We also examined if greater multisystem physiological risk index—derived from inflammatory and cardiometabolic risk markers—mediated the relationship between socioeconomic status (SES) and cerebellar grey matter volume. Both ESES and CSES explained the greatest variance in cerebellar grey matter volume, with age and alcohol use as a covariate in the model. Low CSES explained additional significant variance to low ESES on grey matter decrease. The multisystem physiological risk index mediated the relationship between both early life and current SES and grey matter volume in cerebellum. In a randomly selected sample of neurologically healthy males, poorer socioeconomic status was associated with a smaller cerebellar volume. Early and current socioeconomic status and the multisystem physiological risk index also apparently influence cerebellar volume. These findings provide data on the relationship between socioeconomic deprivation and a brain region highly sensitive to environmental factors.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McConnachie, Dr Alex and Ford, Professor Ian and Tannahill, Dr Carol and Shiels, Professor Paul and Millar, Professor Keith and Cavanagh, Professor Jonathan and Velupillai, Dr Yoganathan and McLean, Dr Jennifer and Batty, Dr G and Packard, Professor Chris and Sattar, Professor Naveed and Krishnadas, Dr Rajeev
Authors: Cavanagh, J., Krishnadas, R., Batty, G.D., Burns, H., Deans, K.A., Ford, I., McConnachie, A., McGinty, A., McLean, J.S., Millar, K., Sattar, N., Shiels, P.G., Tannahill, C., Velupillai, Y.N., Packard, C.J., and McLean, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Cerebellum
Publisher:Springer
ISSN:1473-4222
ISSN (Online):1473-4230

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