Lappin, D., Moseley, H.L. and Whaley, K. (1980) Effect of histamine on monocyte complement production. II. Modulation of protein secretion, degradation and synthesis. Clinical and Experimental Immunology, 42(3), pp. 515-522.
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Abstract
Using immunofluorescence and pulse-label studies with 3H-labelled amino acids, histamine was shown to inhibit the secretion of newly synthesized C2, C4, C3, factor B and beta 1H globulin by monocytes in culture. The findings suggested that protein synthesis was decreased, and that the degradation of newly synthesized intracellular protein was increased in histamine-treated monocytes. The observations that all monocytes in cultures containing histamine stained for C2, C4, and C3, factor B and beta 1H, when secretion was impaired, shows that all monocytes synthesize these proteins. These results demonstrate a negative feedback loop on C3 and C5 cleavage. The anaphylotoxins, C3a and C5a, formed as a result of C3 and C5 cleavage, release histamine from mast cells and basophils. Histamine, by inhibiting the production of C4, C2, and C3 and factor B by mononuclear phagocytes, inhibits further C3 and C5 cleavage by restricting the formation of C42, C423b and C3bBbP.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lappin, Dr David |
| Authors: | Lappin, D., Moseley, H.L., and Whaley, K. |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
| Journal Name: | Clinical and Experimental Immunology |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| ISSN: | 0009-9104 |
| ISSN (Online): | 1365-2249 |
| Related URLs: |
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