Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance

Mwangi, J.M. and Ranford-Cartwright, L.C. (2013) Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance. Parasitology, 140(12), pp. 1455-1467. (doi:10.1017/S0031182013000954)

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Abstract

The biggest threat to the war on malaria is the continued evolution of drug resistance by the parasite. Resistance to almost all currently available antimalarials now exists in Plasmodium falciparum which causes the most suffering among all human malaria parasites. Monitoring of antimalarial efficacy and the development and subsequent spread of resistance has become an important part in the treatment and control of malaria. With recent reports of reduced efficacy of artemisinin, the current recommended treatment for uncomplicated malaria, there is urgent need for better methods to recognize and monitor drug resistance for effective treatment. Molecular markers have become a welcome addition to complement the more laborious and costly in vitro and in vivo methods that have traditionally been used to monitor drug resistance. However, there are currently no molecular markers for resistance to some antimalarials. This review highlights the role of the various genetic and genomic approaches that have been used in identifying the molecular markers that underlie drug resistance in P. falciparum. These approaches include; candidate genes, genetic linkage and genome-wide association studies. We discuss the requirements and limitations of each approach and use various examples to illustrate their contributions in identifying genomic regions of the parasite associated with antimalarial drug responses.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ranford-Cartwright, Dr Lisa and Mwangi, Dr Jonathan
Authors: Mwangi, J.M., and Ranford-Cartwright, L.C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Parasitology
Publisher:Cambridge University Press
ISSN:0031-1820
ISSN (Online):1469-8161
Copyright Holders:Copyright © 2013 Cambridge University Press
First Published:First published in Parasitology 140(2):1455-1467
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
576741Targets of mosquito refractory responses to the human malaria parasite plasmodium falciparumLisa Ranford-CartwrightWellcome Trust (WELLCOME)089891/Z/09/ZIII - PARASITOLOGY
534421Genetic analysis of growth rates in Plasmodium falciparumLisa Ranford-CartwrightWellcome Trust (WELLCOME)091791/Z/10/ZIII - PARASITOLOGY