Clinical and molecular characterization of HER2 amplified-pancreatic cancer

Chou, A. et al. (2013) Clinical and molecular characterization of HER2 amplified-pancreatic cancer. Genome Medicine, 5(8), p. 78. (doi:10.1186/gm482) (PMID:24004612) (PMCID:PMC3978667)

[img]
Preview
Text
86832.pdf - Published Version
Available under License Creative Commons Attribution.

1MB

Abstract

<p>Background: Pancreatic cancer is one of the most lethal and molecularly diverse malignancies. Repurposing of therapeutics that target specific molecular mechanisms in different disease types offers potential for rapid improvements in outcome. Although HER2 amplification occurs in pancreatic cancer, it is inadequately characterized to exploit the potential of anti-HER2 therapies.</p> <p>Methods: HER2 amplification was detected and further analyzed using multiple genomic sequencing approaches. Standardized reference laboratory assays defined HER2 amplification in a large cohort of patients (n = 469) with pancreatic ductal adenocarcinoma (PDAC).</p> <p>Results: An amplified inversion event (1 MB) was identified at the HER2 locus in a patient with PDAC. Using standardized laboratory assays, we established diagnostic criteria for HER2 amplification in PDAC, and observed a prevalence of 2%. Clinically, HER2- amplified PDAC was characterized by a lack of liver metastases, and a preponderance of lung and brain metastases. Excluding breast and gastric cancer, the incidence of HER2-amplified cancers in the USA is >22,000 per annum.</p> <p>Conclusions: HER2 amplification occurs in 2% of PDAC, and has distinct features with implications for clinical practice. The molecular heterogeneity of PDAC implies that even an incidence of 2% represents an attractive target for anti-HER2 therapies, as options for PDAC are limited. Recruiting patients based on HER2 amplification, rather than organ of origin, could make trials of anti-HER2 therapies feasible in less common cancer types.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Biankin, Professor Andrew and Musgrove, Dr Elizabeth and Grimmond, Professor Sean and Chang, Dr David
Authors: Chou, A., Waddell, N., Cowley, M.J., Gill, A.J., Chang, D.K., Patch, A.M., Nones, K., Wu, J., Pinese, M., Johns, A.L., Miller, D.K., Kassahn, K.S., Nagrial, A.M., Wasan, H., Goldstein, D., Toon, C.W., Chin, V., Chantrill, L., Humphris, J., Mead, R., Rooman, I., Samra, J.S., Pajic, M., Musgrove, E.A., Pearson, J.V., Morey, A.L., Grimmond, S.M., and Biankin, A.V.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Genome Medicine
Publisher:BioMed Central
ISSN:1756-994X
ISSN (Online):1756-994X
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Genome Medicine 5(8):78
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record