MicroRNA regulation of endothelial homeostasis and commitment—implications for vascular regeneration strategies using stem cell therapies

Scott, E., Loya, K., Mountford, J., Milligan, G. and Baker, A. H. (2013) MicroRNA regulation of endothelial homeostasis and commitment—implications for vascular regeneration strategies using stem cell therapies. Free Radical Biology and Medicine, 64, pp. 52-60. (doi:10.1016/j.freeradbiomed.2013.04.037)

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Publisher's URL: http://dx.doi.org/10.1016/j.freeradbiomed.2013.04.037

Abstract

Human embryonic (hESC) and induced pluripotent (hiPSC) stem cells have broad therapeutic potential in the treatment of a range of diseases, including those of the vascular system. Both hESCs and hiPSCs have the capacity for indefinite self-renewal, in addition to their ability to differentiate into any adult cell type. These cells could provide a potentially unlimited source of cells for transplantation and, therefore, provide novel treatments, e.g. in the production of endothelial cells for vascular regeneration. MicroRNAs are short, noncoding RNAs that act posttranscriptionally to control gene expression and thereby exert influence over a wide range of cellular processes, including maintenance of pluripotency and differentiation. Expression patterns of these small RNAs are tissue specific, and changes in microRNA levels have often been associated with disease states in humans, including vascular pathologies. Here, we review the roles of microRNAs in endothelial cell function and vascular disease, as well as their role in the differentiation of pluripotent stem cells to the vascular endothelial lineage. Furthermore, we discuss the therapeutic potential of stem cells and how knowledge and manipulation of microRNAs in stem cells may enhance their capacity for vascular regeneration.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Baker, Professor Andrew and Loya, Dr Komal and Mountford, Dr Joanne and Milligan, Professor Graeme
Authors: Scott, E., Loya, K., Mountford, J., Milligan, G., and Baker, A. H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Free Radical Biology and Medicine
Publisher:Elsevier Inc.
ISSN:0891-5849
ISSN (Online):1873-4596
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Studies in Free Radical Biology and Medicine 64:52-60
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
531341In vitro and in vivo analysis of stem cell commitment to vascular endothelial cellsAndrew BakerBritish Heart Foundation (BHF)SP/10/005/28298RI CARDIOVASCULAR & MEDICAL SCIENCES