Scott, E., Loya, K., Mountford, J., Milligan, G. and Baker, A. H. (2013) MicroRNA regulation of endothelial homeostasis and commitment—implications for vascular regeneration strategies using stem cell therapies. Free Radical Biology and Medicine, 64, pp. 52-60. (doi: 10.1016/j.freeradbiomed.2013.04.037)
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Publisher's URL: http://dx.doi.org/10.1016/j.freeradbiomed.2013.04.037
Abstract
Human embryonic (hESC) and induced pluripotent (hiPSC) stem cells have broad therapeutic potential in the treatment of a range of diseases, including those of the vascular system. Both hESCs and hiPSCs have the capacity for indefinite self-renewal, in addition to their ability to differentiate into any adult cell type. These cells could provide a potentially unlimited source of cells for transplantation and, therefore, provide novel treatments, e.g. in the production of endothelial cells for vascular regeneration. MicroRNAs are short, noncoding RNAs that act posttranscriptionally to control gene expression and thereby exert influence over a wide range of cellular processes, including maintenance of pluripotency and differentiation. Expression patterns of these small RNAs are tissue specific, and changes in microRNA levels have often been associated with disease states in humans, including vascular pathologies. Here, we review the roles of microRNAs in endothelial cell function and vascular disease, as well as their role in the differentiation of pluripotent stem cells to the vascular endothelial lineage. Furthermore, we discuss the therapeutic potential of stem cells and how knowledge and manipulation of microRNAs in stem cells may enhance their capacity for vascular regeneration.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Baker, Professor Andrew and Loya, Dr Komal and Mountford, Dr Joanne and Milligan, Professor Graeme |
| Authors: | Scott, E., Loya, K., Mountford, J., Milligan, G., and Baker, A. H. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Free Radical Biology and Medicine |
| Publisher: | Elsevier Inc. |
| ISSN: | 0891-5849 |
| ISSN (Online): | 1873-4596 |
| Copyright Holders: | Copyright © 2013 The Authors |
| First Published: | First published in Studies in Free Radical Biology and Medicine 64:52-60 |
| Publisher Policy: | Reproduced under a Creative Commons License |
| Related URLs: |
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