Bryant, V.C., Kumar, G.D.K., Nyong, A.M. and Natarajan, A. (2012) Synthesis and evaluation of macrocyclic diarylether heptanoid natural products and their analogs. Bioorganic and Medicinal Chemistry Letters, 22(1), pp. 245-248. (doi: 10.1016/j.bmcl.2011.11.025)
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Publisher's URL: http://dx.doi.org/10.1016/j.bmcl.2011.11.025
Abstract
The macrocyclic diarylether heptanoid (MDEH) natural products have been used in folk medicine for centuries. MDEHs are reported to exert anti-tumor properties by inhibiting the activation of NF-κB. Here we report the synthesis of a small MDEH library (first reported synthesis of racemic platycarynol) using a Grubbs cross metathesis/Ullmann cyclization strategy. Evaluation of the library led to the identification of MDEH 9b which sensitizes pancreatic cancer cells to gemcitabine mediated growth inhibition and apoptosis.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gaddale Devanna, Dr Kishore Kumar |
| Authors: | Bryant, V.C., Kumar, G.D.K., Nyong, A.M., and Natarajan, A. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Bioorganic and Medicinal Chemistry Letters |
| ISSN: | 0960-894X |
| ISSN (Online): | 1464-3405 |
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