The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp

Sheiner, L. , Vaidya, A.B. and McFadden, G.I. (2013) The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp. Current Opinion in Microbiology, 16(4), pp. 452-458. (doi:10.1016/j.mib.2013.07.003)

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Abstract

The apicoplast and the mitochondrion of Apicomplexa cooperate in providing essential metabolites. Their co-evolution during the ancestral acquisition of a plastid and subsequent loss of photosynthesis resulted in divergent metabolic pathways compared with mammals and plants. This is most evident in their chimerical haem synthesis pathway. Toxoplasma and Plasmodium mitochondria operate canonical tricarboxylic acid (TCA) cycles and electron transport chains, although the roles differ between Toxoplasma tachyzoites and Plasmodium erythrocytic stages. Glutamine catabolism provides TCA intermediates in both parasites. Isoprenoid precursor synthesis is the only essential role of the apicoplast in Plasmodium erythrocytic stages. An apicoplast-located fatty acid synthesis is dispensable in these stages, which instead predominantly salvage fatty acids, while in Plasmodium liver stages and in Toxoplasma tachyzoites fatty acid synthesis is an essential role of the plastid.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sheiner, Dr Lilach
Authors: Sheiner, L., Vaidya, A.B., and McFadden, G.I.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Opinion in Microbiology
ISSN:1369-5274
ISSN (Online):1879-0364
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