Pawlikowski, J.S., Adams, P.D. and Nelson, D.M. (2013) Senescence at a glance. Journal of Cell Science, 126(18), pp. 4061-4067. (doi: 10.1242/jcs.109728) (PMID:23970414) (PMCID:PMC3772382)
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Abstract
Cellular senescence is a stable proliferation arrest that is associated with extensive cellular remodelling and an altered secretory pathway. Through its numerous inducers that lead to altered gene expression, senescence is able to influence many contrasting functions and pathologies, namely tumour suppression, tumour promotion, wound healing and ageing. As senescence is able to control such important tissue functions, it is now being pinpointed as a possible route for novel therapies. This article and accompanying poster aim to provide a summary of the initiators, pathways and roles of senescence, as well as present examples of senescence and a possible use for senescence in therapy.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Pawlikowski, Mr Jeff and Nelson, Mr David and Adams, Professor Peter |
Authors: | Pawlikowski, J.S., Adams, P.D., and Nelson, D.M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Journal of Cell Science |
ISSN: | 0021-9533 |
ISSN (Online): | 1477-9137 |
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