Distinguishable epidemics of multidrug-resistant Salmonella typhimurium DT104 in different hosts

Mather, A.E. et al. (2013) Distinguishable epidemics of multidrug-resistant Salmonella typhimurium DT104 in different hosts. Science, 341(6153), pp. 1514-1517. (doi:10.1126/science.1240578)

Mather, A.E. et al. (2013) Distinguishable epidemics of multidrug-resistant Salmonella typhimurium DT104 in different hosts. Science, 341(6153), pp. 1514-1517. (doi:10.1126/science.1240578)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.1126/science.1240578

Abstract

The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and its resistance genes were largely maintained within animal and human populations separately and that there was limited transmission, in either direction. We also show considerable variation in the resistance profiles, in contrast to the largely stable bacterial core genome, which emphasizes the critical importance of integrated genotypic data sets in understanding the ecology of bacterial zoonoses and antimicrobial resistance.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Haydon, Professor Daniel and Mellor, Professor Dominic
Authors: Mather, A.E., Reid, S.W.J., Maskell, D.J., Parkhill, J., Fookes, M.C., Harris, S.R., Brown, D.J., Coia, J.E., Mulvey, M.R., Gilmour, M.W., Petrovska, L., de Pinna, E., Kuroda, M., Akiba, M., Izumiya, H., Connor, T.R., Suchard, M.A., Lemey, P., Mellor, D.J., Haydon, D.J., and Thomson, N.R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Science
ISSN:0036-8075
ISSN (Online):1095-9203

University Staff: Request a correction | Enlighten Editors: Update this record