Clark, J.S. and Romiti, F. (2013) Total syntheses of amphidinolides T1, T3, and T4. Angewandte Chemie (International Edition), 52(38), pp. 10072-10075. (doi: 10.1002/anie.201305467)
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Publisher's URL: http://dx.doi.org/10.1002/anie.201305467
Abstract
Concise and high-yielding total syntheses of amphidinolides T1, T3, and T4 have been completed using an alkynyl macrolactone as a common late-stage intermediate. The required α-hydroxy ketone motif was installed by sequential alkyne hydrosilylation, epoxidation, and Fleming-Tamao oxidation. An oxonium ylide rearrangement formed the trisubstituted tetrahydrofuran core found in the natural products.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Clark, Professor Stephen and Romiti, Mr Filippo |
Authors: | Clark, J.S., and Romiti, F. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Angewandte Chemie (International Edition) |
Journal Abbr.: | Angew. Chem. Int. Ed. Engl. |
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
ISSN: | 1433-7851 |
ISSN (Online): | 1521-3773 |
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