Phosphonoacetic acid inhibition of frog virus 3 replication

Elliott, R.M., Bateson, A. and Kelly, D.C. (1980) Phosphonoacetic acid inhibition of frog virus 3 replication. Journal of General Virology, 33(1), pp. 539-542.

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Abstract

Phosphonoacetic acid at concentrations above 200 μg/ml inhibited the replication of frog virus 3 in BHK cells. The inhibition of viral DNA replication observed in these cells was reversible and correlated with the inhibition of the virus-induced DNA polymerase activity in an in vitro assay. The synthesis of frog virus 3-induced late or γ polypeptides was also inhibited by phosphonoacetic acid, although the early (α and β) polypeptides were unaffected.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Elliott, Professor Richard
Authors: Elliott, R.M., Bateson, A., and Kelly, D.C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1098-5514
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