Frog virus 3 replication: Analysis of structural and nonstructural polypeptides in infected BHK cells by acidic and basic two-dimensional gel electrophoresis

Elliott, R.M., Bravo, R. and Kelly, D.C. (1980) Frog virus 3 replication: Analysis of structural and nonstructural polypeptides in infected BHK cells by acidic and basic two-dimensional gel electrophoresis. Journal of Virology, 33(1), pp. 18-27.

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Abstract

Analysis of frog virus 3-infected BHK cells by two-dimensional, acidic and basic gel electrophoresis showed that at least 90 infected cell-specific polypeptides could be detected. These polypeptides represent between 70 and 85% of the coding capacity of the viral genome. The polypeptides were sequentially induced in at least three phases. The virus gradually suppressed host cell polypeptide synthesis during infection, although the synthesis of a few cell polypeptides may be “switched off” early in infection.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Elliott, Professor Richard
Authors: Elliott, R.M., Bravo, R., and Kelly, D.C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Virology
Journal Abbr.:J. Virol.
ISSN:0022-538X
ISSN (Online):1098-5514
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