The replication of frog virus 3 in an amphibian cell line (XTC-2) derived from Xenopus laevis

Elliott, R.M., Arnold, M.K. and Kelly, D.C. (1979) The replication of frog virus 3 in an amphibian cell line (XTC-2) derived from Xenopus laevis. Journal of General Virology, 44(1), pp. 89-97. (doi: 10.1099/0022-1317-44-1-89)

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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-44-1-89

Abstract

Frog virus 3 (FV3) has been demonstrated to replicate in a Xenopus laevis cell line, XTC-2. The virus has been titrated in XTC-2 cells by plaque assay, but the efficiency of plaquing is lower than in minnow or hamster cells. The rate of replication is greater in XTC-2 cells than in BHK cells and this has been correlated with the appearance of virus specific polypeptides in infected cells. Electron microscope observations have shown that FV3 replicates in the cytoplasm of XTC-2 cells and that the virus may leave the cell by budding at the plasma membrane.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Elliott, Professor Richard
Authors: Elliott, R.M., Arnold, M.K., and Kelly, D.C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099

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