Common players in mitochondria biogenesis and neuronal protection against stress-induced apoptosis

Kallergi, E., Kalef-Ezra, E., Karagouni-Dalakoura, K. and Tokatlidis, K. (2014) Common players in mitochondria biogenesis and neuronal protection against stress-induced apoptosis. Neurochemical Research, 39(3), pp. 546-555. (doi:10.1007/s11064-013-1109-x)

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Mitochondria biogenesis is a fundamental process for the organization and normal function of all cells. Since the majority of mitochondrial proteins are synthesized in the cytosol, protein import is the major mechanism for mitochondria biogenesis. We describe the different pathways that ensure correct targeting and intra mitochondrial sorting of mitochondrial proteins. The import process of several proteins of the mitochondrial intermembrane space relies on the Mitochondrial Import and Assembly 40 and Essential for respiration and vegetative growth 1 (Erv1) proteins that together constitute the oxidative folding machinery of the mitochondrial intermembrane space. Recent work has implicated the FAD-oxidase protein Erv1 (ad its human homolog Augmenter of Liver Regeneration) as an anti-apoptotic factor in mammalian cells (including neuronal cells) that undergo Reactive Oxygen Species-triggered apoptosis. The different roles of this protein as a key factor in mitochondria biogenesis, iron-sulfur cluster biogenesis and in neuronal protection against apoptosis are discussed.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Tokatlidis, Professor Kostas
Authors: Kallergi, E., Kalef-Ezra, E., Karagouni-Dalakoura, K., and Tokatlidis, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Neurochemical Research
Publisher:Springer Verlag
ISSN (Online):1573-6903
Published Online:05 September 2013

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