The phage-related chromosomal islands of Gram-positive bacteria

Novick, R.P., Christie, G.E. and Penades, J.R. (2010) The phage-related chromosomal islands of Gram-positive bacteria. Nature Reviews Microbiology, 8, pp. 541-551. (doi:10.1038/nrmicro2393)

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Abstract

The phage-related chromosomal islands (PRCIs) were first identified in Staphylococcus aureus as highly mobile, superantigen-encoding genetic elements known as the S. aureus pathogenicity islands (SaPIs). These elements are characterized by a specific set of phage-related functions that enable them to use the phage reproduction cycle for their own transduction and inhibit phage reproduction in the process. SaPIs produce many phage-like infectious particles; their streptococcal counterparts have a role in gene regulation but may not be infectious. These elements therefore represent phage satellites or parasites, not defective phages. In this Review, we discuss the shared genetic content of PRCIs, their life cycle and their ability to be transferred across large phylogenetic distances.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Penades, Professor Jose R
Authors: Novick, R.P., Christie, G.E., and Penades, J.R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Reviews Microbiology
ISSN:1740-1526
ISSN (Online):1740-1534

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