Rodriguez-Rubio, L., Quiles-Puchalt, N., Martinez, B., Rodriguez, A., Penades, J.R. and Garcia, P. (2013) The peptidoglycan hydrolase of the Staphylococcus aureus bacteriophage 11 plays a structural role in the viral particle. Applied and Environmental Microbiology, 79(19), pp. 6187-6190. (doi: 10.1128/AEM.01388-13)
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Abstract
The role of virion-associated peptidoglycan hydrolases (VAPGHs) in the phage infection cycle is not clear. gp49, the VAPGH from Staphylococcus aureus phage ϕ11, is not essential for phage growth but stabilizes the viral particles. ϕ11Δ49 phages showed a reduced burst size and delayed host lysis. Complementation of gp49 with HydH5 from bacteriophage vB_SauS-phiIPLA88 restored the wild-type phenotype.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Penades, Prof Jose R |
| Authors: | Rodriguez-Rubio, L., Quiles-Puchalt, N., Martinez, B., Rodriguez, A., Penades, J.R., and Garcia, P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Applied and Environmental Microbiology |
| Publisher: | American Society for Microbiology |
| ISSN: | 0099-2240 |
| ISSN (Online): | 1098-5336 |
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