Detecting recombination with MCMC

Husmeier, D. and McGuire, G. (2002) Detecting recombination with MCMC. Bioinformatics, 18(Sup 1), S345-S353. (doi:10.1093/bioinformatics/18.suppl_1.S345)

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Abstract

Motivation: We present a statistical method for detecting recombination, whose objective is to accurately locate the recombinant breakpoints in DNA sequence alignments of small numbers of taxa (4 or 5). Our approach explicitly models the sequence of phylogenetic tree topologies along a multiple sequence alignment. Inference under this model is done in a Bayesian way, using Markov chain Monte Carlo (MCMC). The algorithm returns the site-dependent posterior probability of each tree topology, which is used for detecting recombinant regions and locating their breakpoints.

Results: The method was tested on a synthetic and three real DNA sequence alignments, where it was found to outperform the established detection methods PLATO, RECPARS, and TOPAL.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Husmeier, Professor Dirk
Authors: Husmeier, D., and McGuire, G.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Statistics
Journal Name:Bioinformatics
ISSN:1367-4803
ISSN (Online):1460-2059

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