TOPALi: software for automatic identification of recombinant sequences within DNA multiple alignments

Milne, I., Wright, F., Rowe, G., Marshall, D.F., Husmeier, D. and McGuire, G. (2004) TOPALi: software for automatic identification of recombinant sequences within DNA multiple alignments. Bioinformatics, 20(11), pp. 1806-1807. (doi:10.1093/bioinformatics/bth155)

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Abstract

TOPALi is a new Java graphical analysis application that allows the user to identify recombinant sequences within a DNA multiple alignment (either automatically or via manual investigation). TOPALi allows a choice of three statistical methods to predict the positions of breakpoints due to past recombination. The breakpoint predictions are then used to identify putative recombinant sequences and their relationships to other sequences. In addition to its sophisticated interface, TOPALi can import many sequence formats, estimate and display phylogenetic trees and allow interactive analysis and/or automatic HTML report generation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Husmeier, Professor Dirk
Authors: Milne, I., Wright, F., Rowe, G., Marshall, D.F., Husmeier, D., and McGuire, G.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Statistics
Journal Name:Bioinformatics
ISSN:1367-4803
ISSN (Online):1460-2059

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