IL-12 and related cytokines: function and regulatory implications in candida albicans infection

Ashman, R.B., Vijayan, D. and Wells, C.A. (2011) IL-12 and related cytokines: function and regulatory implications in candida albicans infection. Clinical and Developmental Immunology, 2011, Art. 686597. (doi: 10.1155/2011/686597)

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Abstract

IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wells, Dr Christine
Authors: Ashman, R.B., Vijayan, D., and Wells, C.A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Clinical and Developmental Immunology
Publisher:Hindawi Publishing Corporation
ISSN:1740-2522
ISSN (Online):1740-2530
Copyright Holders:Copyright © 2011 The Authors
First Published:First published in Clinical and Developmental Immunology 2011:686597
Publisher Policy:Reproduced under a Creative Commons License

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