Telomere length and physical performance at older ages: an individual participant meta-analysis

Gardner, M.P. et al. (2013) Telomere length and physical performance at older ages: an individual participant meta-analysis. PLoS ONE, 8(7), e69526. (doi:10.1371/journal.pone.0069526) (PMID:23922731) (PMCID:PMC3724915)

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Abstract

<p>Background: Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence for such an association is lacking. The purpose of this study was to examine whether change in telomere length is associated with physical performance.</p> <p>Methods: Using data from four UK adult cohorts (ages 53–80 years at baseline), we undertook cross-sectional and longitudinal analyses. We analysed each study separately and then used meta-analytic methods to pool the results. Physical performance was measured using walking and chair rise speed, standing balance time and grip strength. Telomere length was measured by quantitative real-time polymerase chain reaction (PCR) in whole blood at baseline and follow-up (time 1, time 2).</p> <p>Results: Total sample sizes in meta-analyses ranged from 1,217 to 3,707. There was little evidence that telomere length was associated with walking speed, balance or grip strength, though weak associations were seen with chair rise speed and grip strength at baseline (p = 0.02 and 0.01 respectively). Faster chair rise speed at follow-up, was associated with a smaller decline in telomere length between time 1 and time 2 (standardised coefficient per SD increase 0.061, 95% CI 0.006, 0.115, p = 0.03) but this was consistent with chance (p = 0.08) after further adjustment.</p> <p>Conclusions: Whereas shortening of leukocyte telomeres might be an important measure of cellular ageing, there is little evidence that it is a strong biomarker for physical performance.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Shiels, Professor Paul
Authors: Gardner, M.P., Martin-Ruiz, C., Cooper, R., Hardy, R., Sayer, A.A., Cooper, C., Deary, I.J., Gallacher, J., Harris, S.E., Shiels, P.G., Starr, J.M., Kuh, D., von Zglinicki, T., and Ben-Shlomo, Y.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN:1932-6203
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in PLoS ONE 8(7):e69526
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
476082A life course approach to healthy ageing: capitalising on the value of the UK life course cohortsPaul ShielsEconomic & Social Research Council (ESRC)RES-353-25-0001RI CANCER SCIENCES