Comparison of visual and automated assessment of microvessel density and their impact on outcome in primary operable invasive ductal breast cancer

Mohammed, Z.M.A., Orange, C., McMillan, D.C. , Mallon, E., Doughty, J.C., Edwards, J. and Going, J.J. (2013) Comparison of visual and automated assessment of microvessel density and their impact on outcome in primary operable invasive ductal breast cancer. Human Pathology, 44(8), pp. 1688-1695. (doi:10.1016/j.humpath.2012.11.023)

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Abstract

Angiogenesis is essential for tumor growth and metastasis, and several studies have reported increased angiogenesis, as quantified by microvessel density, to be a powerful prognostic tool in breast cancer. Therefore, there is considerable interest in automated assessment of microvessel density with possible benefits in improved accuracy, increased precision, and handling workload. Visual and automated assessment of microvessel density (CD34+) and survival were examined in patients with primary operable invasive ductal breast cancer. Tissue microarrays (n = 356 patients) immunostained for microvessel density (CD34+) were scored visually and automatically with the Slidepath Tissue IA system (Dublin, Ireland). Visual and automated microvessel density (CD34+) were in agreement (interclass correlation coefficient = 0.69, P < .001). Visual but not the automated method for microvessel density (CD34+) was associated with locoregional treatment and metastasis. On univariate survival analysis, visual but not automated method for microvessel density (CD34+) was associated with recurrence-free and cancer-specific survival in patients with invasive ductal breast cancer (P < .01). Although automated assessment of microvessel density (CD34+) is in reasonable agreement, it poorly predicts outcome in patients with operable invasive ductal breast cancer.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMillan, Professor Donald and Orange, Miss Clare and Mallon, Dr Elizabeth and Going, Dr James and Edwards, Professor Joanne and Doughty, Miss Julie
Authors: Mohammed, Z.M.A., Orange, C., McMillan, D.C., Mallon, E., Doughty, J.C., Edwards, J., and Going, J.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Human Pathology
ISSN:0046-8177

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