Signalling pathways and gene expression profiles in prostate cancer

Marsella-Hatziieremia, S., McCall, P. and Edwards, J. (2011) Signalling pathways and gene expression profiles in prostate cancer. In: Spiess, P. (ed.) Prostate Cancer: From Bench to Bedside. InTech, pp. 93-114. ISBN 9789533073316 (doi: 10.5772/26971)

Abstract

In general, cancer, encompassing prostate cancer (PCa), is a disease that utilises signalling pathways to progress through the uncontrolled proliferation of cancerous cells. Although the mechanisms of how the cells evade intrinsic or extrinsic signals of death and keep on dividing is not completely understood, there is a plethora of evidence that point to certain signalling molecules that are crucial conveyors of the fine tuning that slightly differs in cancer in comparison to control states. The present chapter provides a detailed description of the key regulators of PCa cell life and unveils their closely communicating proteins that aid in the fine tuning of the cancerous state.

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: Edwards, Professor Joanne and McCall, Dr Pamela
• Authors: Marsella-Hatziieremia, S., McCall, P., and Edwards, J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Publisher: InTech
• ISBN: 9789533073316
• Copyright Holders: Copyright © 2011 The Authors
• First Published: First published in Prostate Cancer: From Bench to Bedside Chapter 5:93-114
• Publisher Policy: Reproduced under a Creative Commons License