High-resolution fMRI reveals laminar differences in neurovascular coupling between positive and negative BOLD responses

Goense, J., Merkle, H. and Logothetis, N.K. (2012) High-resolution fMRI reveals laminar differences in neurovascular coupling between positive and negative BOLD responses. Neuron, 76(3), pp. 629-639. (doi:10.1016/j.neuron.2012.09.019)

Full text not currently available from Enlighten.

Abstract

The six cortical layers have distinct anatomical and physiological properties, like different energy use and different feedforward and feedback connectivity. It is not known if and how layer-specific neural processes are reflected in the fMRI signal. To address this question we used high-resolution fMRI to measure BOLD, CBV, and CBF responses to stimuli that elicit positive and negative BOLD signals in macaque primary visual cortex. We found that regions with positive BOLD responses had parallel increases in CBV and CBF, whereas areas with negative BOLD responses showed a decrease in CBF but an increase in CBV. For positive BOLD responses, CBF and CBV increased in the center of the cortex, but for negative BOLD responses, CBF decreased superficially while CBV increased in the center. Our findings suggest different mechanisms for neurovascular coupling for BOLD increases and decreases, as well as laminar differences in neurovascular coupling.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Goense, Dr Jozien
Authors: Goense, J., Merkle, H., and Logothetis, N.K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Neuron
ISSN:0896-6273
ISSN (Online):1097-4199

University Staff: Request a correction | Enlighten Editors: Update this record