Zarros, A. , Byrne, A.-M., Boomkamp, S.D., Tsakiris, S. and Baillie, G.S. (2013) Lanthanum-induced neurotoxicity: solving the riddle of its involvement in cognitive impairment? Archives of Toxicology, 87(11), pp. 2031-2035. (doi: 10.1007/s00204-013-1112-7) (PMID:23934103)
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Abstract
The conclusion of a series of recent reports highlights the significant neurotoxic effects that rare earth elements, such as lanthanum (La), can have during neurodevelopment. These findings are, herein, combined and presented using a simplified schematic overview that provides a putative solution to the riddle of La-induced cognitive impairment. Our commentary also highlights potential targets for further investigations into the mechanisms which underpin La-induced neurotoxicity, with a focus on the crucial role of the hippocampus. Within this context, a central role for the cyclic-adenosine monophosphate signalling pathway is proposed.
| Item Type: | Articles (Letter) |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Baillie, Professor George and Zarros, Dr Apostolos and Boomkamp, Dr Stephanie |
| Authors: | Zarros, A., Byrne, A.-M., Boomkamp, S.D., Tsakiris, S., and Baillie, G.S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Archives of Toxicology |
| Publisher: | Springer Verlag |
| ISSN: | 0340-5761 |
| ISSN (Online): | 1432-0738 |
| Published Online: | 10 August 2013 |
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