Lanthanum-induced neurotoxicity: solving the riddle of its involvement in cognitive impairment?

Zarros, A., Byrne, A.-M., Boomkamp, S.D., Tsakiris, S. and Baillie, G.S. (2013) Lanthanum-induced neurotoxicity: solving the riddle of its involvement in cognitive impairment? Archives of Toxicology, 87(11), pp. 2031-2035. (doi:10.1007/s00204-013-1112-7) (PMID:23934103)

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Abstract

The conclusion of a series of recent reports highlights the significant neurotoxic effects that rare earth elements, such as lanthanum (La), can have during neurodevelopment. These findings are, herein, combined and presented using a simplified schematic overview that provides a putative solution to the riddle of La-induced cognitive impairment. Our commentary also highlights potential targets for further investigations into the mechanisms which underpin La-induced neurotoxicity, with a focus on the crucial role of the hippocampus. Within this context, a central role for the cyclic-adenosine monophosphate signalling pathway is proposed.

Item Type:Articles (Letter)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Baillie, Professor George and Zarros, Dr Apostolos and Boomkamp, Dr Stephanie
Authors: Zarros, A., Byrne, A.-M., Boomkamp, S.D., Tsakiris, S., and Baillie, G.S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Archives of Toxicology
Publisher:Springer Verlag
ISSN:0340-5761
ISSN (Online):1432-0738
Published Online:10 August 2013

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