RACK(1) to the future – a historical perspective

Ron, D., Adams, D.R., Baillie, G.S. , Long, A., O’Connor, R. and Kiely, P.A. (2013) RACK(1) to the future – a historical perspective. Cell Communication and Signaling, 11(53), (doi:10.1186/1478-811X-11-53)

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Publisher's URL: http://dx.doi.org/10.1186/1478-811X-11-53

Abstract

This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1’s role in the immune system, the heart and the brain were discussed and its contribution to disease states such as cancer, cardiac hypertrophy and addiction were described. RACK1 is a scaffolding protein and a member of the WD repeat family of proteins. These proteins have a unique architectural assembly that facilitates protein anchoring and the stabilisation of protein activity. A large body of evidence is accumulating which is helping to define the versatile role of RACK1 in assembling and dismantling complex signaling pathways from the cell membrane to the nucleus in health and disease. In this commentary, we first provide a historical perspective on RACK1. We also address many of the pertinent and topical questions about this protein such as its role in transcription, epigenetics and translation, its cytoskeletal contribution and the merits of targeting RACK1 in disease.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Baillie, Professor George
Authors: Ron, D., Adams, D.R., Baillie, G.S., Long, A., O’Connor, R., and Kiely, P.A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Cell Communication and Signaling
ISSN:1478-811X
ISSN (Online):1873-961X
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Cell Communication and Signaling 11(53)
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
588611cAMP phosphodiesterase-4: signalling complexes, regulation and potential therapeutic targets.George BaillieMedical Research Council (MRC)MR/J007412/1RI CARDIOVASCULAR & MEDICAL SCIENCES