Impaired renal function impacts negatively on vascular stiffness in patients with coronary artery disease

Rossi, S. H. et al. (2013) Impaired renal function impacts negatively on vascular stiffness in patients with coronary artery disease. BMC Nephrology, 14(173), (doi: 10.1186/1471-2369-14-173)

Abstract

<p>Background Chronic kidney disease (CKD) and coronary artery disease (CAD) are independently associated with increased vascular stiffness. We examined whether renal function contributes to vascular stiffness independently of CAD status.</p> <p>Methods We studied 160 patients with CAD and 169 subjects without CAD. The 4-variable MDRD formula was used to estimate glomerular filtration rate (eGFR); impaired renal function was defined as eGFR <60 mL/min. Carotid-femoral pulse wave velocity (PWV) was measured with the SphygmoCor® device. Circulating biomarkers were assessed in plasma using xMAP® multiplexing technology.</p> <p>Results Patients with CAD and impaired renal function had greater PWV compared to those with CAD and normal renal function (10.2 [9.1;11.2] vs 7.3 [6.9;7.7] m/s; P < 0.001). In all patients, PWV was a function of eGFR (β = −0.293; P< 0.001) even after adjustment for age, sex, systolic blood pressure, body mass index and presence or absence of CAD. Patients with CAD and impaired renal function had higher levels of adhesion and inflammatory molecules including E-selectin and osteopontin (all P< 0.05) compared to those with CAD alone, but had similar levels of markers of oxidative stress.</p> <p>Conclusions Renal function is a determinant of vascular stiffness even in patients with severe atherosclerotic disease. This was paralleled by differences in markers of cell adhesion and inflammation. Increased vascular stiffness may therefore be linked to inflammatory remodeling of the vasculature in people with impaired renal function, irrespective of concomitant atherosclerotic disease.</p>

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Taurino, Dr Chiara and McQuarrie, Dr Emily and Dymott, Dr Jane and Miller, Dr Ashley and Moreno Zulategui, Dr Maria de Ujue and Neisius, Dr Ulf and Rossi, Miss Sabrina and Dominiczak, Professor Anna and Delles, Professor Christian and MacKenzie, Dr Ruth and Miller, Dr William
• Authors: Rossi, S. H., McQuarrie, E. P., Miller, W. H., MacKenzie, R. M., Dymott, J. A., Moreno, M. U., Taurino, C., Miller, A. M., Neisius, U., Berg, G. A., Valuckiene, Z., Hannay, J. A., Dominiczak, A. F., and Delles, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: BMC Nephrology
• Publisher: BioMed Central
• ISSN: 1471-2369
• ISSN (Online): 1471-2369
• Copyright Holders: Copyright © 2013 The Authors
• First Published: First published in BMC Nephrology 14(173)
• Publisher Policy: Reproduced under a Creative Commons License

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Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
48361	1	Interleukin-33: A Novel Cytokine in the Inflammation of Atherosclerosis and Obesity	Ashley Miller	British Heart Foundation (BHF)	FS/08/035/25309	III -IMMUNOLOGY
48361	2	Interleukin-33: A Novel Cytokine in the Inflammation of Atherosclerosis and Obesity	Ashley Miller	British Heart Foundation (BHF)	FS/08/035/25309	III -IMMUNOLOGY