The eye as a model of ageing in translational research – molecular, epigenetic and clinical aspects

Pathai, S., Shiels, P.G. , Lawn, S.D., Cook, C. and Gilbert, C. (2013) The eye as a model of ageing in translational research – molecular, epigenetic and clinical aspects. Ageing Research Reviews, 12(2), pp. 490-508. (doi:10.1016/j.arr.2012.11.002)

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Abstract

The eye and visual system are valuable in many areas of translational research such as stem cell therapy, transplantation research and gene therapy. Changes in many ocular tissues can be measured directly, easily and objectively in vivo (e.g. lens transparency; retinal blood vessel calibre; corneal endothelial cell counts) and so the eye may also be a uniquely useful site as a model of ageing. This review details cellular, molecular and epigenetic mechanisms related to ageing within the eye, and describes ocular parameters that can be directly measured clinically and which might be of value in ageing research as the translational “window to the rest of the body”. The eye is likely to provide a valuable model for validating biomarkers of ageing at molecular, epigenetic, cellular and clinical levels. A research agenda to definitively establish the relationship between biomarkers of ageing and ocular parameters is proposed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Shiels, Professor Paul
Authors: Pathai, S., Shiels, P.G., Lawn, S.D., Cook, C., and Gilbert, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Ageing Research Reviews
ISSN:1568-1637
ISSN (Online):1872-9649

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