Tribbles in acute leukemia

Liang, K.L., Rishi, L. and Keeshan, K. (2013) Tribbles in acute leukemia. Blood, 121(21), pp. 4265-4270. (doi:10.1182/blood-2012-12-471300)

Full text not currently available from Enlighten.

Abstract

There is growing research interest in the mammalian Tribbles (Trib) family of serine/threonine pseudokinases and their oncogenic association with acute leukemias. This review is to understand the role of Trib genes in hematopoietic malignancies and their potential as targets for novel therapeutic strategies in acute myeloid leukemia and acute lymphoblastic leukemia. We discuss the role of Tribs as central signaling mediators in different subtypes of acute leukemia and propose that inhibition of dysregulated Trib signaling may be therapeutically beneficial.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Keeshan, Dr Karen
Authors: Liang, K.L., Rishi, L., and Keeshan, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Blood
Publisher:American Society of Hematology
ISSN:0006-4971
ISSN (Online):1528-0020

University Staff: Request a correction | Enlighten Editors: Update this record