Gilfillan, L., Blair, A., Morris, B. , Pratt, J., Schweiger, L., Pimlott, S. and Sutherland, A. (2013) Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones; potential imaging agents of the metabotropic glutamate 2 receptor. MedChemComm, 4(7), pp. 1118-1123. (doi: 10.1039/c3md00110e)
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Abstract
A focused library of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones containing sites for 11C-, 18F- and 123I-labelling have been prepared and evaluated against membrane expressing human recombinant metabotropic glutamate 2 receptor (mGluR2). The compounds were found to be non-competitive antagonists with nanomolar affinity. HPLC evaluation of the physiochemical properties of these compounds identified two candidates for PET and SPECT imaging of mGluR2.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Pimlott, Dr Sally and Pratt, Dr Judith and Haahr, Dr Lynne and Sutherland, Professor Andrew and Morris, Professor Brian |
Authors: | Gilfillan, L., Blair, A., Morris, B., Pratt, J., Schweiger, L., Pimlott, S., and Sutherland, A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing College of Science and Engineering > School of Chemistry |
Journal Name: | MedChemComm |
Publisher: | Royal Society of Chemistry |
ISSN: | 2040-2503 |
ISSN (Online): | 2040-2511 |
Copyright Holders: | Copyright © 2013 The Authors |
First Published: | First published in MedChemComm 4(7):1118-1123 |
Publisher Policy: | Reproduced under a Creative Commons License |
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