Adult cardiac-resident msc-like stem cells with a proepicardial origin

Chong, J.J.H. et al. (2011) Adult cardiac-resident msc-like stem cells with a proepicardial origin. Cell Stem Cell, 9(6), pp. 527-540. (doi:10.1016/j.stem.2011.10.002)

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Colony-forming units – fibroblast (CFU-Fs), analogous to those giving rise to bone marrow (BM) mesenchymal stem cells (MSCs), are present in many organs, although the relationship between BM and organ-specific CFU-Fs in homeostasis and tissue repair is unknown. Here we describe a population of adult cardiac-resident CFU-Fs (cCFU-Fs) that occupy a perivascular, adventitial niche and show broad trans-germ layer potency in vitro and in vivo. CRE lineage tracing and embryo analysis demonstrated a proepicardial origin for cCFU-Fs. Furthermore, in BM transplantation chimeras, we found no interchange between BM and cCFU-Fs after aging, myocardial infarction, or BM stem cell mobilization. BM and cardiac and aortic CFU-Fs had distinct CRE lineage signatures, indicating that they arise from different progenitor beds during development. These diverse origins for CFU-Fs suggest an underlying basis for differentiation biases seen in different CFU-F populations, and could also influence their capacity for participating in tissue repair.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Biankin, Professor Andrew
Authors: Chong, J.J.H., Chandrakanthan, V., Xaymardan, M., Asli, N.S., Li, J., Ahmed, I., Heffernan, C., Menon, M.K., Scarlett, C.J., Rashidianfar, A., Biben, C., Zoellner, H., Colvin, E.K., Pimanda, J.E., Biankin, A.V., Zhou, B., Pu, W.T., Prall, O.W.J., and Harvey, R.P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cell Stem Cell
ISSN (Online):1875-9777

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