New Substituted Peptide Compounds are Beta Transducin Repeat-Containing Protein Modulators, Useful for Treating e.g. Breast Cancer, Arthritis, Osteoarthritis, Rheumatoid Arthritis, Crohn's Disease and Irritable Bowel Syndrome

Iti Scotland Limited (2013) New Substituted Peptide Compounds are Beta Transducin Repeat-Containing Protein Modulators, Useful for Treating e.g. Breast Cancer, Arthritis, Osteoarthritis, Rheumatoid Arthritis, Crohn's Disease and Irritable Bowel Syndrome. .

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Abstract

The present invention relates to compounds which bind to Beta Trans-ducin repeat-containing protein (PTrCP), and modulate the activity of l3TrCP. In particular, the invention relates to compounds which demonstrate optimised binding to PTrCP. The invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds as medicaments, specifically for the treatment of disorders associated with aberrant protein degradation, such as cancer. The preferred binding inhibitors are peptides derived from the motive DSGXXS, e.g. DEGFWE, DDGFWD and Succinyl-EGFWE

Item Type:Patents
Additional Information:Patent Number: WO2013001297-A1.
Status:Published
Glasgow Author(s) Enlighten ID:Baillie, Professor George
Authors: Bradley, M., Walton, J.G.A., Chankeshwara, S.V., Sleiman, M., Baillie, G.S., and Gibson, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology

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