Insulin resistance in type 1 diabetes: what is ‘double diabetes’ and what are the risks?

Cleland, S.J., Fisher, B.M., Colhoun, H.M., Sattar, N. and Petrie, J.R. (2013) Insulin resistance in type 1 diabetes: what is ‘double diabetes’ and what are the risks? Diabetologia, 56(7), pp. 1462-1470. (doi: 10.1007/s00125-013-2904-2)

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In this review, we explore the concept of ‘double diabetes’, a combination of type 1 diabetes with features of insulin resistance and type 2 diabetes. After considering whether double diabetes is a useful concept, we discuss potential mechanisms of increased insulin resistance in type 1 diabetes before examining the extent to which double diabetes might increase the risk of cardiovascular disease (CVD). We then go on to consider the proposal that weight gain from intensive insulin regimens may be associated with increased CV risk factors in some patients with type 1 diabetes, and explore the complex relationships between weight gain, insulin resistance, glycaemic control and CV outcome. Important comparisons and contrasts between type 1 diabetes and type 2 diabetes are highlighted in terms of hepatic fat, fat partitioning and lipid profile, and how these may differ between type 1 diabetic patients with and without double diabetes. In so doing, we hope this work will stimulate much-needed research in this area and an improvement in clinical practice.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Petrie, Professor John and Sattar, Professor Naveed
Authors: Cleland, S.J., Fisher, B.M., Colhoun, H.M., Sattar, N., and Petrie, J.R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Diabetologia
ISSN (Online):1432-0428
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Diabetologia 56(7):1462-1470
Publisher Policy:Reproduced under a Creative Commons License

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