Parker, A.C., Pritchard, P., Preston, T., and Choonara, I. (1998) Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test. British Journal of Clinical Pharmacology, 45 (2). pp. 176-178. ISSN 0306-5251 (doi:10.1046/j.1365-2125.1998.00684.x)
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Publisher's URL: http://dx.doi.org/10.1046/j.1365-2125.1998.00684.x
Aims: Carbamazepine is a known enzyme inducer. The aim of this study was to determine whether carbamazepine induces the metabolism of caffeine in children. Methods: Children due to receive carbamazepine for epilepsy were recruited into the study. The caffeine breath test was carried out prior to the administration of carbamazepine and after a minimum of 2–3 weeks therapy. Five children were studied and they received 200–600 mg carbamazepine daily. Results The mean values of the 2 h cumulative labelled carbon dioxide were 3.47% before and 7.65% during carbamazepine. There was a significant increase in the percentage labelled caffeine exhaled as carbon dioxide during the administration of carbamazepine (Student's paired t-test, P<0.05). Conclusions: The results suggest that carbamazepine induces the metabolism of caffeine by the CYP1A2 pathway in the children studied.
|Keywords:||Caffeine, carbamazepine, children, caffeine breath test, enzyme induction, CYP1A2|
|Glasgow Author(s):||Preston, Prof Thomas|
|Authors:||Parker, A.C., Pritchard, P., Preston, T., and Choonara, I.|
|Subjects:||Q Science > QH Natural history > QH345 Biochemistry|
|College/School:||College of Science and Engineering > Scottish Universities Environmental Research Centre|
|Journal Name:||British Journal of Clinical Pharmacology|
|Journal Abbr.:||Br. J. Clin. Pharmacol.|
|Published Online:||4 January 2002|