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Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test

Parker, A.C., Pritchard, P., Preston, T., and Choonara, I. (1998) Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test. British Journal of Clinical Pharmacology, 45 (2). pp. 176-178. ISSN 0306-5251 (doi:10.1046/j.1365-2125.1998.00684.x)

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Publisher's URL: http://dx.doi.org/10.1046/j.1365-2125.1998.00684.x

Abstract

Aims: Carbamazepine is a known enzyme inducer. The aim of this study was to determine whether carbamazepine induces the metabolism of caffeine in children. Methods: Children due to receive carbamazepine for epilepsy were recruited into the study. The caffeine breath test was carried out prior to the administration of carbamazepine and after a minimum of 2–3 weeks therapy. Five children were studied and they received 200–600 mg carbamazepine daily. Results The mean values of the 2 h cumulative labelled carbon dioxide were 3.47% before and 7.65% during carbamazepine. There was a significant increase in the percentage labelled caffeine exhaled as carbon dioxide during the administration of carbamazepine (Student's paired t-test, P<0.05). Conclusions: The results suggest that carbamazepine induces the metabolism of caffeine by the CYP1A2 pathway in the children studied.

Item Type:Article
Keywords:Caffeine, carbamazepine, children, caffeine breath test, enzyme induction, CYP1A2
Status:Published
Refereed:Yes
Glasgow Author(s):Preston, Prof Thomas
Authors: Parker, A.C., Pritchard, P., Preston, T., and Choonara, I.
Subjects:Q Science > QH Natural history > QH345 Biochemistry
College/School:College of Science and Engineering > Scottish Universities Environmental Research Centre
Journal Name:British Journal of Clinical Pharmacology
Journal Abbr.:Br. J. Clin. Pharmacol.
ISSN:0306-5251
ISSN (Online):1365-2125
Published Online:4 January 2002

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