Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease

Robinson, M. W., McGuinness, D., Swann, R., Barclay, S., Mills, P. R., Patel, A. H., McLauchlan, J. and Shiels, P. G. (2013) Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease. Aging Cell, 12(6), pp. 1141-1143. (doi:10.1111/acel.12125) (PMID:23931242)

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Abstract

Chronic hepatitis C virus infection (C-HC) is associated with higher mortality arising from hepatic and extrahepatic disease. This may be due to accelerated biological aging; however, studies in C-HC have thus far been based solely on telomere length as a biomarker of aging (BoA). In this study, we have evaluated CDKN2 locus transcripts as alternative BoAs in C-HC. Our results suggest that C-HC induces non-cell-autonomous senescence and accelerates biological aging. The CDKN2 locus may provide a link between C-HC and increased susceptibility to age-associated diseases and provides novel biomarkers for assessing its impact on aging processes in man.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Robinson, Dr Mark and Mills, Professor Peter and Swann, Rachael and Shiels, Professor Paul and McGuinness, Dr Dagmara and Patel, Professor Arvind and McLauchlan, Professor John
Authors: Robinson, M. W., McGuinness, D., Swann, R., Barclay, S., Mills, P. R., Patel, A. H., McLauchlan, J., and Shiels, P. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Aging Cell
Publisher:Anatomical Society and John Wiley & Sons Ltd.
ISSN:1474-9718
ISSN (Online):1474-9726
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Aging Cell 12(6):1141-1143
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656341Virus-host interactions in hepatitis C virus infectionJohn MclauchlanMedical Research Council (MRC)MC_UU_12014/1MVLS III - CENTRE FOR VIRUS RESEARCH
656491Basis of the host range and tissue tropism for hepatitis C virusArvind PatelMedical Research Council (MRC)MC_UU_12014/2MVLS III - CENTRE FOR VIRUS RESEARCH