Alterations in vascular function in primary aldosteronism - a cardiovascular magnetic resonance imaging study

Mark, P.B. , Boyle, S., Zimmerli, L.U., McQuarrie, E.P., Delles, C. and Freel, E.M. (2014) Alterations in vascular function in primary aldosteronism - a cardiovascular magnetic resonance imaging study. Journal of Human Hypertension, 28(2), pp. 92-97. (doi: 10.1038/jhh.2013.70)

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Introduction: Excess aldosterone is associated with increased cardiovascular risk. Aldosterone has a permissive effect on vascular fibrosis. Cardiovascular magnetic resonance imaging (CMR) allows study of vascular function by measuring aortic distensibility. We compared aortic distensibility in primary aldosteronism (PA), essential hypertension (EH) and normal controls and explored the relationship between aortic distensibility and pulse wave velocity (PWV).<p></p> Methods: We studied PA (n=14) and EH (n=33) subjects and age-matched healthy controls (n=17) with CMR, including measurement of aortic distensibility, and measured PWV using applanation tonometry. At recruitment, PA and EH patients had similar blood pressure and left ventricular mass.<p></p> Results: Subjects with PA had significantly lower aortic distensibilty and higher PWV compared to EH and healthy controls. These changes were independent of other factors associated with reduced aortic distensibility, including aging. There was a significant relationship between increasing aortic stiffness and age in keeping with physical and vascular aging. As expected, aortic distensibility and PWV were closely correlated.<p></p> Conclusion: These results demonstrate that PA patients display increased arterial stiffness compared to EH, independent of vascular aging. The implication is that aldosterone invokes functional impairment of arterial function. The long-term implications of arterial stiffening in aldosterone excess require further study.<p></p>

Item Type:Articles
Glasgow Author(s) Enlighten ID:McQuarrie, Dr Emily and Boyle, Mr Stephen and Freel, Dr Marie and Mark, Professor Patrick and Delles, Professor Christian and Zimmerli, Dr Lukas
Authors: Mark, P.B., Boyle, S., Zimmerli, L.U., McQuarrie, E.P., Delles, C., and Freel, E.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Human Hypertension
Publisher:Nature Publishing Group
ISSN (Online):1476-5527
Copyright Holders:Copyright © 2014 Nature Publishing Group
First Published:First published in Journal of Human Hypertension 28(2):92-97
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.
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