Cant, A.A., Champion, S. , Bhalla, R., Pimlott, S.L. and Sutherland, A. (2013) Nickel-mediated radioiodination of aryl and heteroaryl bromides: rapid synthesis of tracers for SPECT imaging. Angewandte Chemie (International Edition), 52(30), pp. 7829-7832. (doi: 10.1002/anie.201302800)
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Abstract
Rapid and efficient radioiodination of aryl and heteroaryl bromides has been achieved using a nickel(0)-mediated halogen-exchange reaction. This transformation gives direct access to [<sup>123</sup>I]- and [<sup>125</sup>II]-imaging agents for single photon emission computed tomography (SPECT), such as 5-[<sup>123</sup>I]-A85380 (see scheme, Boc=tert-butyloxycarbonyl, cod=1,5-cyclooctadiene, TFA=trifluoroacetic acid).
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Pimlott, Dr Sally and Champion, Dr Sue and Cant, Mr Alastair and Sutherland, Professor Andrew |
Authors: | Cant, A.A., Champion, S., Bhalla, R., Pimlott, S.L., and Sutherland, A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing College of Science and Engineering > School of Chemistry |
Journal Name: | Angewandte Chemie (International Edition) |
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
ISSN: | 1433-7851 |
ISSN (Online): | 1521-3773 |
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