Nickel-mediated radioiodination of aryl and heteroaryl bromides: rapid synthesis of tracers for SPECT imaging

Cant, A.A., Champion, S. , Bhalla, R., Pimlott, S.L. and Sutherland, A. (2013) Nickel-mediated radioiodination of aryl and heteroaryl bromides: rapid synthesis of tracers for SPECT imaging. Angewandte Chemie (International Edition), 52(30), pp. 7829-7832. (doi: 10.1002/anie.201302800)

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Abstract

Rapid and efficient radioiodination of aryl and heteroaryl bromides has been achieved using a nickel(0)-mediated halogen-exchange reaction. This transformation gives direct access to [<sup>123</sup>I]- and [<sup>125</sup>II]-imaging agents for single photon emission computed tomography (SPECT), such as 5-[<sup>123</sup>I]-A85380 (see scheme, Boc=tert-butyloxycarbonyl, cod=1,5-cyclooctadiene, TFA=trifluoroacetic acid).

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Pimlott, Dr Sally and Champion, Dr Sue and Sutherland, Professor Andrew and Cant, Mr Alastair
Authors: Cant, A.A., Champion, S., Bhalla, R., Pimlott, S.L., and Sutherland, A.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Science and Engineering > School of Chemistry
Journal Name:Angewandte Chemie (International Edition)
Publisher:Wiley - V C H Verlag GmbH & Co. KGaA
ISSN:1433-7851
ISSN (Online):1521-3773

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