Dickens, N.J. and Ponting, C.P. (2003) THoR: a tool for domain discovery and curation of multiple alignments. Genome Biology, 4(8), R52. (doi: 10.1186/gb-2003-4-8-r52) (PMID:12914660) (PMCID:PMC193644)
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81572.pdf - Published Version 232kB |
Abstract
We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Dickens, Dr Nicholas |
| Authors: | Dickens, N.J., and Ponting, C.P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Genome Biology |
| Publisher: | BioMed Central |
| ISSN: | 1465-6914 |
| ISSN (Online): | 1465-6914 |
| Copyright Holders: | Copyright © 2003 The Authors |
| First Published: | First published in Genome Biology 4(8):R52 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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