Targeting self-renewal pathways in myeloid malignancies

Sands, W.A., Copland, M. and Wheadon, H. (2013) Targeting self-renewal pathways in myeloid malignancies. Cell Communication and Signaling, 11(33), (doi:10.1186/1478-811X-11-33)

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Abstract

A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through transcriptional networks. Key activators/regulators of self-renewal include chemokines, cytokines and morphogens which are expressed in the bone marrow niche, either in a paracrine or autocrine fashion, and modulate stem cell behaviour. Increasing evidence suggests that the downstream signaling pathways induced by these ligands converge at multiple levels providing a degree of redundancy in steady state hematopoiesis. Here we will focus on how these pathways cross-talk to regulate HSC self-renewal highlighting potential therapeutic windows which could be targeted to prevent leukemic stem cell self-renewal in myeloid malignancies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sands, Dr William and Copland, Professor Mhairi and Wheadon, Dr Helen
Authors: Sands, W.A., Copland, M., and Wheadon, H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cell Communication and Signaling
Publisher:BioMed Central
ISSN:1478-811X
ISSN (Online):1478-811X
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Cell Communication and Signaling 11(33)
Publisher Policy:Reproduced under a Creative Commons License

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