Christiansen, E. et al. (2013) Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes. ACS Medicinal Chemistry Letters, 4(5), pp. 441-445. (doi: 10.1021/ml4000673)
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Abstract
Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Jenkins, Mrs Laura and Hudson, Dr Brian and Milligan, Professor Graeme |
Authors: | Christiansen, E., Hansen, S.V.F., Urban, C., Hudson, B.D., Wargent, E.T., Grundmann, M., Jenkins, L., Zaibi, M., Stocker, C.J., Ullrich, S., Kostenis, E., Kassack, M.U., Milligan, G., Cawthorne, M.A., and Ulven, T. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | ACS Medicinal Chemistry Letters |
Publisher: | American Chemical Society |
ISSN: | 1948-5875 |
ISSN (Online): | 1948-5875 |
Copyright Holders: | Copyright © 2013 American Chemical Society |
First Published: | First published in ACS Medicinal Chemistry Letters |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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