The subcutaneous movements of filarial infective larvae are impaired in vaccinated hosts in comparison to primary infected hosts

Babayan, S.A. , Attout, T., Vuong, P.N., Le Goff, L., Gantier, J. and Bain, O. (2005) The subcutaneous movements of filarial infective larvae are impaired in vaccinated hosts in comparison to primary infected hosts. Filaria Journal, 4(3), (doi: 10.1186/1475-2883-4-3)

Abstract

Our aim in this study was to observe the movements of filarial infective larvae following inoculation into the mammalian host and to assess the effect of vaccination on larval migration, in situ. Here we present recordings of larvae progressing through the subcutaneous tissues and inguinal lymph node of primary infected or vaccinated mice. We used the filaria Litomosoides sigmodontis in BALB/c mice that were necropsied 6 hours after the challenge inoculation of 200 larvae. Subcutaneous tissue sections were taken from the inoculation site and larvae were filmed in order to quantify their movements. Our analyses showed that the subcutaneous larvae were less motile in the vaccinated mice than in primary-infected mice and had more leucocytes attached to the cuticle. We propose that this reduced motility may result in the failure of a majority of larvae to evade the inflammatory reaction, thereby being a possible mechanism involved in the early vaccine-induced protection.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Babayan, Dr Simon
• Authors: Babayan, S.A., Attout, T., Vuong, P.N., Le Goff, L., Gantier, J., and Bain, O.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Filaria Journal
• Publisher: BioMed Central
• ISSN: 1475-2883
• Copyright Holders: Copyright © 2005 The Authors
• First Published: First published in Filaria Journal 4:3
• Publisher Policy: Reproduced under a Creative Commons License