McQuaker, S. J., Quinlan, C. L., Caldwell, S. T. , Brand, M. D. and Hartley, R. C. (2013) A prototypical small-molecule modulator uncouples mitochondria in response to endogenous hydrogen peroxide production. ChemBioChem, 14(8), pp. 993-1000. (doi: 10.1002/cbic.201300115) (PMID:23640856) (PMCID:PMC3743171)
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Abstract
A high membrane potential across the mitochondrial inner membrane leads to the production of the reactive oxygen species (ROS) implicated in aging and age-related diseases. A prototypical drug for the correction of this type of mitochondrial dysfunction is presented. MitoDNP-SUM accumulates in mitochondria in response to the membrane potential due to its mitochondria-targeting alkyltriphenylphosphonium (TPP) cation and is uncaged by endogenous hydrogen peroxide to release the mitochondrial uncoupler, 2,4-dinitrophenol (DNP). DNP is known to reduce the high membrane potential responsible for the production of ROS. The approach potentially represents a general method for the delivery of drugs to the mitochondrial matrix through mitochondria targeting and H2O2-induced uncaging.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Caldwell, Dr Stuart and Hartley, Professor Richard |
Authors: | McQuaker, S. J., Quinlan, C. L., Caldwell, S. T., Brand, M. D., and Hartley, R. C. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | ChemBioChem |
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
ISSN: | 1439-4227 |
ISSN (Online): | 1439-7633 |
Copyright Holders: | Copyright © 2013 The Authors |
First Published: | First published in ChemBioChem 14(8):993-1000 |
Publisher Policy: | Reproduced under a Creative Commons License |
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