Self-folding nano- and micropatterned hydrogel tissue engineering scaffolds by single step photolithographic process

Vasiev, I., Greer, A.I.M., Khokhar, A.Z., Stormonth-Darling, J. , Tanner, K.E. and Gadegaard, N. (2013) Self-folding nano- and micropatterned hydrogel tissue engineering scaffolds by single step photolithographic process. Microelectronic Engineering, 108, pp. 76-81. (doi:10.1016/j.mee.2013.04.003)

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Abstract

Current progress in tissue engineering is focused on the creation of environments in which cultures of relevant cells can adhere, grow and form functional tissue. We propose a method for controlled chemical and topographical cues through surface patterning of self-folding hydrogel films. This provides a conversion of 2D patterning techniques into a viable method of manufacturing a 3D scaffold. While similar bilayers have previously been demonstrated, here we present a faster and high throughput process for fabricating self-folding hydrogel devices incorporating controllable surface nanotopographies by serial hot embossing of sacrificial layers and photolithography.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Tanner, Professor K and Khokhar, Dr Ali and Stormonth-Darling, Mr John and Greer, Mr Andrew and Gadegaard, Professor Nikolaj
Authors: Vasiev, I., Greer, A.I.M., Khokhar, A.Z., Stormonth-Darling, J., Tanner, K.E., and Gadegaard, N.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Microelectronic Engineering
Publisher:Elsevier
ISSN:0167-9317
ISSN (Online):1873-5568
Copyright Holders:Copyright © 2013 Elsevier B.V.
First Published:First published in Microelectronic Engineering 108:76-81
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
554791EPSRC Doctoral Training Grant 2010-14Mary Beth KneafseyEngineering & Physical Sciences Research Council (EPSRC)EP/P505534/1VICE PRINCIPAL RESEARCH & ENTERPRISE
554792EPSRC Doctoral Training Grant 2010-14Mary Beth KneafseyEngineering & Physical Sciences Research Council (EPSRC)EP/P505534/1VICE PRINCIPAL RESEARCH & ENTERPRISE
554793EPSRC Doctoral Training Grant 2010-14Mary Beth KneafseyEngineering & Physical Sciences Research Council (EPSRC)EP/P505534/1VICE PRINCIPAL RESEARCH & ENTERPRISE
518721Engineering and Physical Sciences Doctoral Training Grant 2009-13Mary GoodmanEngineering & Physical Sciences Research Council (EPSRC)EP/P504937/1VICE PRINCIPAL RESEARCH & ENTERPRISE
518722Engineering and Physical Sciences Doctoral Training Grant 2009-13Mary GoodmanEngineering & Physical Sciences Research Council (EPSRC)EP/P504937VICE PRINCIPAL RESEARCH & ENTERPRISE