An adaptable peptide-based porous material

Rabone, J. et al. (2010) An adaptable peptide-based porous material. Science, 329(5995), pp. 1053-1057. (doi:10.1126/science.1190672)

Full text not currently available from Enlighten.

Abstract

Porous materials find widespread application in storage, separation, and catalytic technologies. We report a crystalline porous solid with adaptable porosity, in which a simple dipeptide linker is arranged in a regular array by coordination to metal centers. Experiments reinforced by molecular dynamics simulations showed that low-energy torsions and displacements of the peptides enabled the available pore volume to evolve smoothly from zero as the guest loading increased. The observed cooperative feedback in sorption isotherms resembled the response of proteins undergoing conformational selection, suggesting an energy landscape similar to that required for protein folding. The flexible peptide linker was shown to play the pivotal role in changing the pore conformation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ganin, Dr Alexey
Authors: Rabone, J., Yue, Y.- F., Chong, S.Y., Stylianou, K.C., Bacsa, J., Bradshaw, D., Darling, G.R., Berry, N.G., Khimyak, Y.Z., Ganin, A.Y., Wiper, P., Claridge, J.B., and Rosseinsky, M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Science
Publisher:American Association for the Advancement of Science
ISSN:0036-8075

University Staff: Request a correction | Enlighten Editors: Update this record