Regulation of cardiovascular remodeling by the counter-regulatory axis of the renin–angiotensin system

Clarke, C., Flores-Muñoz, M., McKinney, C. A., Milligan, G. and Nicklin, S. A. (2013) Regulation of cardiovascular remodeling by the counter-regulatory axis of the renin–angiotensin system. Future Cardiology, 9(1), pp. 23-38. (doi:10.2217/fca.12.75)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.2217/fca.12.75

Abstract

The counter-regulatory axis of the renin–angiotensin system (RAS) is a novel therapeutic target in cardiovascular disease. Pathophysiological effects mediated via angiotensin II (Ang II) are well established in regulation of blood pressure, cardiac and vascular remodeling, and renal sodium handling, which lead to disorders such as hypertension and associated end-organ damage, atherosclerosis and heart failure. The counter-regulatory axis of the RAS is centered on the angiotensin-converting enzyme 2/angiotensin-1–7 (Ang-[1–7])/Mas receptor axis and has been shown to inhibit many detrimental phenotypes in cardiovascular disease. More recently, an alternative peptide, angiotensin-(1-9) (Ang-[1-9]), has been reported as a potential new member of this axis. This review will discuss the cardiovascular regulatory roles of Ang-(1–7) and Ang-(1–9) in the counter-regulatory axis of the RAS, and the potential for new therapeutic approaches in cardiovascular disease.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nicklin, Professor Stuart and Clarke, Dr Carolyn and Milligan, Professor Graeme
Authors: Clarke, C., Flores-Muñoz, M., McKinney, C. A., Milligan, G., and Nicklin, S. A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Future Cardiology
Publisher:Future Medicine Ltd.
ISSN:1479-6678
ISSN (Online):1744-8298
Related URLs:

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
519461Dissecting the mechanism of action of the novel renin angiotensin hormone angiotensin1-9Stuart NicklinMedical Research Council (MRC)G0901161RI CARDIOVASCULAR & MEDICAL SCIENCES
570291Angiotensin 1-9 and angiotensin 1-7: assessment of their mechanisms of action as counter-regulatory renin angiotensin system peptides in cardiovascular diseaseStuart NicklinBritish Heart Foundation (BHF)PG/11/43/28901RI CARDIOVASCULAR & MEDICAL SCIENCES