Antibodies against cell surface antigens as very potent immunological adjuvants

Barr, T., Carlring, J., Hatzifoti, C. and Heath, A.W. (2006) Antibodies against cell surface antigens as very potent immunological adjuvants. Vaccine, 24(Sup 2), S20-S21. (doi:10.1016/j.vaccine.2005.01.105)

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Abstract

We describe here two very potent adjuvant systems which are thought to work directly on antigen specific lymphocytes, thus by-passing the normal route for adjuvants, which is to activate antigen presenting cells (APCs) inducing release of inflammatory cytokines with resultant side effects of local and systemic reactogenicity. CD40 and CD28 based adjuvants are extremely potent and should avoid the inflammatory side effects induced by most adjuvants.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Barr, Dr Tom
Authors: Barr, T., Carlring, J., Hatzifoti, C., and Heath, A.W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Vaccine
ISSN:0264-410X

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