Dying and necrotic neutrophils are anti-inflammatory secondary to the release of α-defensins

Miles, K., Clarke, D.J., Lu, W., Sibinska, Z., Beaumont, P.E., Davidson, D.J., Barr, T.A., Campopiano, D.J. and Gray, M. (2009) Dying and necrotic neutrophils are anti-inflammatory secondary to the release of α-defensins. Journal of Immunology, 183(3), pp. 2122-2132. (doi:10.4049/jimmunol.0804187)

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Abstract

Neutrophils are recruited to sites of injury but their timely removal is thought to be vital to prevent exacerbating inflammation. In addition, the recognition of apoptotic cells by cells of the innate immune system provides potent anti-inflammatory and anti-immunogenic signals. In this article, we describe how human neutrophils dying by apoptosis or necrosis release anti-inflammatory peptides, the α-defensins. This family of small cationic peptides effectively inhibits the secretion of multiple proinflammatory cytokines and NO from macrophages, the main innate immune cell found at sites of chronic inflammation. In addition, the systemic administration of necrotic neutrophil supernatants and α-defensins protects mice from a murine model of peritonitis. Hence. their effects may be far-reaching and serve to kill microbes while regulating a potentially tissue-destructive inflammatory response.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Barr, Dr Tom
Authors: Miles, K., Clarke, D.J., Lu, W., Sibinska, Z., Beaumont, P.E., Davidson, D.J., Barr, T.A., Campopiano, D.J., and Gray, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Immunology
ISSN:0022-1767

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