B cells: programmers of CD4 T cell responses

Barr, T.A., Gray, M. and Gray, D. (2012) B cells: programmers of CD4 T cell responses. Infectious Disorders - Drug Targets, 12(3), pp. 222-231. (doi:10.2174/187152612800564446)

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Abstract

B cells are once again gaining prominence as important programmers of CD4 T cell responses. With widespread use of B cell depletion therapy in the clinic, proving effective in treating diseases previously considered T cellmediated, the time is right for a re-appraisal of the B cell. Though typically considered weak, Th2 driving APC, it is now clear that they are necessary for a robust and long-lived CD4 T cell response in many settings. The sphere of B cell influence extends well beyond that of simply antibody production; antigen presentation, cytokine secretion, costimulation and development of lymphoid tissue architecture are all critical aspects of B cell immunobiology, the absence of which has serious impacts for T cell priming and memory. The aim of this review is to look at non-antibody mediated B cell function and to ask how, where and when do B cells influence the CD4 T cell response?

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Barr, Dr Tom
Authors: Barr, T.A., Gray, M., and Gray, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Infectious Disorders - Drug Targets
ISSN:1871-5265
ISSN (Online):2212-3989

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