Apoptotic proteins: p53 and c-myc related pathways

McCarthy, N., Mercer, J.R. and Bennett, M. (2001) Apoptotic proteins: p53 and c-myc related pathways. Cardiology Clinics, 19(1), pp. 75-89. (doi: 10.1016/S0733-8651(05)70196-X)

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Abstract

Much of the research into apoptosis has centered on neuronal, immunologic, and tumor cell models. Hence, the molecular control mechanisms that regulate apoptosis are interpreted in the context of the requirements of these specific tissues. Clearly, tissues have very different characteristics, suggesting that even though cells may express similar genes, the effects of these genes can be different between cell types. Cells within the vasculature have their own endogenous and exogenous signals that determine cell differentiation, cell proliferation, and apoptosis. Although many of these are common to other cell types, vascular-specific apoptotic, survival, and regulatory signals are also present. This article examines the role of two genes involved in the regulation of apoptosis: (1) the tumor suppressor gene product p53 and (2) the proto-oncogene c-myc. The roles of these genes in carcinogenesis are well documented, 50 and 83 but their role in normal and diseased cells within the vasculature has yet to be fully elucidated. In particular, the authors examine whether the biological functions of these genes in tumor models are applicable to their roles in vascular cells.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mercer, Dr John
Authors: McCarthy, N., Mercer, J.R., and Bennett, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Cardiology Clinics
ISSN:0733-8651

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